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Veenat-Imatinib Veenat contains imatinib and belongs to a class of medications known as protein-tyrosine kinase inhibitor.   Indication Veenat is used for the treatment of a type of leukemia (chronic myeloid leukemia or cml), gastrointestinal stromal tumors (gists - a type of tumor that grows in the walls of the digestive passages and may spread to other parts of the body). Veenat may also be used to prevent cancer from growing in patients after surgical removal of gist.   Mechanism of Action Veenat works by blocking the action of an abnormal protein that promotes the multiplication of cancer cells. This helps slow or stop the spread of cancer cells. Supplied as:veenat is available in 100mg & 400mg tablets or capsules.   Dosage: Veenat is usually taken once a day. Overdose:symptoms of overdose associated with veenat may include diarrhea, yellowing eyes and skin, stomach pain, fever, swelling, dark urine, change in amount of urine (severe increase or decrease), headache, loss of appetite, unusual bruising or bleeding, unusual tiredness or weakness, vomiting.   Precautions & Warnings Veenat should not be taken without consulting your doctor if you have ever had pulmonary fibrosis (scarring of the lungs), or liver or kidney disease, bone marrow problems, low white blood cell levels, or low blood platelet levels or if you have had your thyroid gland removed and if you have a history of swelling (edema) or fluid retention.   Drug Interactions The following drugs may interact with veenat: The side effects including the risk of bleeding may be increased by warfarin The risk of veenat's side effects may be increased by azole antifungals (itraconazole, ketoconazole), ketolide antibiotics (telithromycin), macrolide antibiotics (clarithromycin, erythromycin), nefazodone, or protease inhibitors (ritonavir) Other cancer drugs (tamoxifen), corticosteroids (prednisone), cyclosporine, tacrolimus, cisapride, calcium channel blockers (diltiazem, verapamil), heart rhythm drugs (amiodarone, quinidine), certain diabetes medications (glipizide, pioglitazone, troglitazone), rifampin, st. John's wort, nsaids (ibuprofen), antidepressants (desipramine, fluoxetine, paroxetine), beta-blockers (propranolol)
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