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Description

Brand Name:

Valcyte

Generic Name:

Valganclclovir

Company:

Roche

Strength:

450mg

Packing:

1x1

Type:

Tablet

Uses:

HIV


Valcyte contains Valganclclovir

It is used in the treatment of cytomegalovirus retinitis in aids patients.Valgancyclovir is initially phosphorylated to the monophosphate form by viral protein kinase, then it is further phosphorylated via cellular kinases to produce the triphosphate form. This triphosphate form is slowly metabolized intracellularly. The phosphorylation is dependent upon the viral kinase and occurs preferentially in virus-infected cells. The virustatic activity of valgancyclovir is due to the inhibition of viral DNA synthesis by valgancyclovir triphosphate. Valgancyclovir triphosphate is incorporated into the DNA strand replacing many of the bases. This results in the prevention of DNA synthesis, destabilizing the strand, inhibits viral DNA polymerases more effectively than it does cellular polymerase.

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