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  • BrandTagrisso
Osimertinib Trade name: Tagrisso™

Osimertinib is the generic name for the trade drug Tagrisso™. In some cases, health care professionals may use the trade name Tagrisso™ when referring to the generic drug name osimertinib.

Drug type: Osimertinib is a targeted therapy. It is an oral EGFR Kinase inhibitor - (For more detail, see "How this drug works," below.)

What osimertinib is used for:
  • For the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by FDA-approved test, who have progressed on or after EGFR TKII therapy.

Note: if a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How osimertinib is given:
  • Osimertinib is a pill, taken by mouth, one daily. It can be taken with or without food.
  • Take osimertinib exactly as prescribed
  • Try to swallow osimertinib tablets whole.
  • If you cannot swallow osimertinib tablets whole:
    • Plase your dose of osimertinib in a container that contains 2 ounces of water. Do not use carbonated water or any other liquids
    • Stir the osimertinib tablet and water until the tablet is in small pieces (the tablet will not completely dissolve). Do not crush or heat.
    • Drink the osimertinib and water mixture right away.
    • Add 4 to 8 ounces of water to the container and drink to make sure you take your full dose.
  • Do not change your dose or stop osimertinib unless your health care provider tells you to.
  • If you miss a dose, skip the missed dose and take your next dose at your regular time.
  • Do not take more than 1 dose of osimertinib at one time. Call your health care provider right away if you take too much.

The amount of osimertinib that you will receive depends on many factors, your general health or other health problems, and the type of cancer or condition being treated. Higher doeses do not give a better response and may cause increased toxicity. Your doctor will determine your dose and schedule.

Side effects:
Important things to remember about the side effects of osimertinib:
  • Most people do not experience all of the side effects listed.
  • Side effects are often predictable in terms of their onset and duration.
  • Side effects are almost always reversible and will go away after treatment is complete.
  • There are many options to help minimize or prevent side effects.
  • There is no relationship between the presence or severity of side effects and the effectiveness of the medication.

The following side effects are common (occuring in greater than 30%) for patients taking osimertinib:
  • Decrease in white blood cells (total number; cells needed to fight infection)
  • Low platelets
  • Anemia
  • Diarrhea
  • Skin rash
  • Neutroipenia (decrease in neutrophils- a type of white blood cell)
  • Dry skin

These side effects are less common side effects (occuring in about 10-29%) of patients receiving osimertinib:
  • Low sodium
  • Nail changes
  • High magnesium levels
  • Eye disorder (including dry eyes, blurred vision, keratitis, cataract, eye irritation, blepharitis, eye pain, increase tear production, floaters)
  • Nausea
  • Decreased appetite
  • Constipation
  • Fatigue
  • Cough
  • Itching
  • Back pain
  • Mouth sores
  • Headache

Not all side effects are listed above. Some that are rare (occuring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.    
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