Sefix-400 Capsules
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Sefix-400 Capsules
CLINICAL PHARMACOLOGY:
Peak serum concentrations occur between 2 and 6 hours following oral administration of a single 200 mg capsule , a single 400 mg capsule.
Approximately 50% of the absorbed dose is excreted unchanged in the urine in 24 hours.
The serum half-life of cefixime in healthy subjects is independent of dosage from and averages 3 to 4 hours, but may range up to 9 hours in some normal volunteers.
In subjects with moderate impairment of renal function (20 to 40 ml/min creatinine clearance), the average serum half-life of cefixime is prolonged to 6.4 hours. In severe renal impairment (5 to 20 ml/min creatinine clearance) the half-life increased to an average of 11.5 hours. The drug is not cleared significantly from the blood by hemodialysis.
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Sefix-400 Capsules
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