DACLAHEP 60 MG TABELETS

Daclatasvir was discovered as a first-in-class inhibitor of the non-structural viral protein 5A (NS5A), a phosphoprotein that plays an important role in hepatitis C replication. The exact mechanism by which daclatasvir inhibits the NS5A replication complex is unclear, but it is believed that daclatasvir inhibits viral RNA replication and virion assembly. It may also inhibit phosphorylation of the NS4A, and therefore the formation and activation of the HCV replication complex. Based on in vitro data, daclatasvir has shown activity against HCV genotypes 1 through 6, with EC50 values ranging from picomolar to low nanomolar against wild type HCV.