- BrandEMED Pharmacy
Item Code: CARDIO01
Composition
Bosentan 125mg
Typical usage: Pulomonary artery hypertension (PAH), systemic sclerosis for digital ulcers.
Side Effects: Nausea, stomach pain, loss of appetite, dark urine, clay-colored stools; or jaundice (yellowing of the skin or eyes), headache, flushing, swelling of the feet, ankles, or legs, dizziness, upset stomach, fatigue; or tching.
Drug Interaction: Some products that may interact with this drug include: cyclosporine, glyburide. Other medications can affect the removal of bosentan from your body, which may affect how bosentan works. Examples include anti-seizure drugs including carbamazepine, azole antifungals including itraconazole/ketoconazole, macrolide antibiotics including erythromycin, HIV protease inhibitors including ritonavir, rifamycins including rifabutin, amiodarone, cimetidine, tacrolimus, St. John's wort, among others. This drug can speed up the removal of other drugs from your body, which may affect how they work. Examples of affected drugs include "statin" cholesterol medications (such as simvastatin, lovastatin), warfarin, among others. This medication may decrease the effectiveness of combination-type hormonal birth control (e.g., pills, patch). This effect can result in pregnancy. You may need to use an additional form of reliable, non-hormonal birth control (e.g., condom, diaphragm with spermicide) while using this medication.
Mechanism Of Action: Bosentan is used to treat high blood pressure in the lungs (pulmonary arterial hypertension). This condition is thought to be caused by increased levels of a certain natural substance (endothelin-1). This medication blocks the effects of endothelin-1, thereby helping to decrease the blood pressure in the lungs, slow the worsening of symptoms from the disease, and improve your ability to exercise.