Azith Tablets

Following oral administration in humans, azithromycin is widely distributed throughout the body, bio availability is approximately 37%. No significant decrease in bio-availability was observed when azithromycin tablets were administered with a meal. The time taken to peak plasma levels is 2-3 hours. Plasma terminal elimination half-life closely reflects the tissue depletion half-life of 2 to 4 days.
Kinetic studies of variable times ranging from hours to days after oral intake have shown markedly higher azithromycin levels in tissue than in plasma (up to 50 times the maximum observed concentration in plasma) indicating that the drug is highly tissue bound. Concentrations in target tissues such as lung, tonsil and prostate exceed the mic90 for likely pathogens after a single dose of 500 mg. In vitro sensitivity does not necessarily imply in vivo efficacy. Azithromycin demonstrates activity in vitro against a wide range of gram-positive and gram-negative bacteria including: staphylococcus aureus; streptococcus pneumoniae, streptococcus pyogenes (group a) and other streptococcus species; haemophilus influenzae; moraxella catarrhalis; bordetella pertussis; borrelia burgdorferi; haemophilus ducreyi; and chlamydia trachomatis. Azithromycin also demonstrates in vitro activity against mycoplasma pneumoniae and treponema pallidum.